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Elucidating the regulated expression of the prion protein mRNA in the rat brain: a novel circadian rhythm
Reference
9912337
Principal Investigator / Supervisor
Professor Clive Coen
Co-Investigators /
Co-Supervisors
Institution
King's College London
Department
Institute of Psychiatry
Funding type
Research
Value (£)
53,650
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/06/2002
Duration
26 months
Abstract
We have discovered a circadian rhythm in prion protein (PrPc ) mRNA expression through the rat forebrain. Understanding this dynamic regulation will elucidate the control of circadian rhythms that are synchronised across multiple sites; furthermore, since PrPc expression governs susceptibility to TSEs, identification of the underlying processes may have therapeutic significance. We will investigate whether the co-ordinated rise in the mRNA (1) is a consequence of rhythmic activity in various endocrine systems, (2) is dependent upon D-box binding proteins, a rhythmically expressed transcription factor which binds to the prion gene promoter and (3) is governed by either the light- entrainable or the food-entrainable oscillator.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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