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Toll-like receptors and the host response to Salmonella enterica
Reference
9912336
Principal Investigator / Supervisor
Professor Duncan Maskell
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Veterinary Medicine
Funding type
Research
Value (£)
177,268
Status
Completed
Type
Research Grant
Start date
07/02/2000
End date
07/08/2002
Duration
30 months
Abstract
Salmonella species cause a wide range of disease syndromes in many animals, including all the most important farm species. We have shown that Salmonella typhimurium lipopolysaccharide (LPS) plays a critical role in causing death in lethal mouse typhoid infections probably via generation of inappropriately high levels of cytokine mediators. Recent work suggests that Toll-like receptors are involved in mediating signalling responses to LPS. In this study we will investigate the hypothesis that the protective immune response as well as the lethality seen in different Salmonella infections in mice are both dependent on LPS interactions with Toll-like receptors.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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