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Proteomic analysis of focal adhesions
Reference
9912334
Principal Investigator / Supervisor
Professor Martin Humphries
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
89,869
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
01/03/2002
Duration
24 months
Abstract
Focal adhesions are specialised regions of the plasma membrane that play essential roles in cell adhesion and signalling. The molecular composition of focal adhesions is very complex and highly dynamic. A major challenge faced by the field is to develop methods to analyse focal adhesion structures in an integrated way. The specific aims of the project are to assess (a) whether proteomic analysis is an appropriate technology for detecting focal adhesion components in a comprehensive manner, and (b) whether changes in signalling as measured by the molecular composition of focal adhesions, can be detected under different conditions of receptor occupancy.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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