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Award details
NA+-channel gated Na+-selective electrode for determination of paralytic poisons
Reference
9912308
Principal Investigator / Supervisor
Professor Elizabeth Hall
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Institute of Biotechnology
Funding type
Research
Value (£)
91,203
Status
Completed
Type
Research Grant
Start date
27/03/2000
End date
27/03/2002
Duration
24 months
Abstract
This project seeks to make a new bioanalytical system which exploits the voltage dependent membrane sodium channel to pump sodium to a sodium ion selective electrode. The purpose is to determine analytes (or other species) which act on the sodium channel to influence sodium flux through the channel. The project is catalysed by consideration of a method for detection of paralytic fish poisoning, which acts on the sodium channel, but is not uniquely focussed to this application. A novel hybrid Na+ membrane is proposed with a lipid bilayer upon a Na+ ion selective membrane, the latter being of the alkyl methacrylate family. The success depends on stabilising the Na+ bilayer, but also compatibility with the underlying ion-selective layers. The new self-plasticising ion-selective polymers proposed here are critical, since no plasticiser is present in the ion-selective membrane which exude from the membrane and partition into the lipid bilayer.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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