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Influence of caveolae-mediated uptake of respiratory syncytial virus by dendritic cells on immune response
Reference
9912306
Principal Investigator / Supervisor
Dr Geraldine Taylor
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
99,114
Status
Completed
Type
Research Grant
Start date
10/01/2000
End date
10/01/2002
Duration
24 months
Abstract
We propose to investigate whether the novel mechanism of cavelae-mediated uptake of respiratory syncytial virus by cattle dendritic cells, that we have recently established, influences the type of immune response that is generated. Thus, can the immune response be manipulated by changing the route of entry of virus into the cell so that (1) a different sub- cellular compartment is targeted or (2) the response of the dendritic cell is changed and (3) the immune response induced is changed. Any could potentially change the type of response that is generated in vivo and consequently affect subsequent immunity.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1999 (ROPA1999) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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