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Towards synthetic plant disease resistance (R) genes; construction and screening of large R gene libraries
Reference
9810755
Principal Investigator / Supervisor
Professor Jonathan Jones
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
138,538
Status
Completed
Type
Research Grant
Start date
01/01/1999
End date
01/02/2001
Duration
25 months
Abstract
Plant disease resistance (R) genes confer resistance to pathogen races carrying corresponding avirulence (Avr) genes. Most R genes encode leucine rich repeat (LRR) proteins that are probably receptors for Avr-encoded ligands. R gene homologue sequence comparison reveals evolution by recombination between gene family members. Pronounced amino acid variability is observed in solvent exposed amino acids of a putative parallel beta sheet recognition surface. Using oligonucleotide mutagenesis and sexual PCR to promote in vitro recombination between R gene homologues, we will create libraries of R gene alleles and select synthetic R genes targeted to both defined and undefined pathogen ligands.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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