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Clean synthesis of novel carbocyclic nucleosides using the A chain of diptheria toxin
Reference
9810750
Principal Investigator / Supervisor
Dr Gary Robinson
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
University of Kent Department
Funding type
Research
Value (£)
69,391
Status
Completed
Type
Research Grant
Start date
01/11/1998
End date
01/05/2000
Duration
18 months
Abstract
Clean synthesis is a central focus for both the BBSRC and EPSRC. The present proposal will, for the first time, use a subunit of a well characterised bacterial toxin, diphtheria, for the chemical synthesis of novel antiviral carbocyclic nucleosides. The project will use the A subunit of diphtheria toxin (DTA), a non-toxic, non-cofactor requiring and robust (retains activity at 100 degrees C and pH2-12) protein which ordinarily catalyses the ADP-ribsosylation of EF-2. The latter simply represents the transfer of a ribosyl moiety to N-1 the imidazole ring of diphthamide, a post- translationally modified histidine residue present in EF-2. This proposal will investigate whether alternative ribosyl and carbocyclic moieties can be coupled to various imidazole containing purine molecules to yield the target compounds.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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