Award details

Novel strategies for identifying signal sensing and transducing factors in plant pathogenic fungi

Reference	9810723
Principal Investigator / Supervisor	Professor John Lucas
Co-Investigators / Co-Supervisors
Institution	Rothamsted Research
Department	Sustainable Soils and Grassland Systems
Funding type	Research
Value (£)	46,600
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	01/04/2000
Duration	12 months

Abstract

Many plant pathogenic fungi initiate the disease process by sensing external stimuli and forming infection structures on the surface of the host plant. This proposal aims to develop a novel strategy for identifying genes involved in signal sensing and infection structure induction using the cereal eyespot pathogen Tapesia yallundae as a model system. The strategy uses an inducible fungal promoter coupled to a toxin subunit gene which is only active within transformed cells under inducing conditions. Hence this can be used as a powerful positive selection system to efficiently screen large numbers of mutants affected in signal perception and transduction pathways essential for pathogenesis. Mutations identified by this method will be used to clone and characterise the corresponding wild-type genes, some of which will represent novel targets for chemical intervention.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	ROPA 1998 (ROPA1998) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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