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Peptides as probes of chemoreception in nematodes: a new basis for transgenic crop resistance
Reference
9810713
Principal Investigator / Supervisor
Prof. Howard Atkinson
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Plant Biochemistry & Biotechnology
Funding type
Research
Value (£)
100,728
Status
Completed
Type
Research Grant
Start date
23/03/1999
End date
23/12/2001
Duration
33 months
Abstract
Phage display will be used to define peptides that disrupt chemoreception. The mode of action of the peptides on amphidial sensillae will be defined. Acetylcholine esterase and kinesin in nematode chemoreceptive neurones will be targeted as the pesticides aldicarb and ivermectin disrupt chemoreception by interaction with these two proteins respectively. Those peptides that disrupt chemoreception in bioassays will be expressed in hairy roots to provide proof of principle for the new approach. A novel basis for future nematode control via transgenic plants will be provided. Fundamental understanding of chemoreception in these important crop pests will be improved.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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