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The role of oestrogen in neural development in the hypothalamus
Reference
9810682
Principal Investigator / Supervisor
Professor Fran Ebling
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
34,367
Status
Completed
Type
Research Grant
Start date
01/03/1999
End date
01/08/2002
Duration
41 months
Abstract
Steroid hormones play an important role in the sexual differentiation of neuroendocrine systems in the hypothalamus and in regulating their function in adult life. Oestrogen has recently been shown to enhance axonal growth and branching and to retard neurodegeneration in other areas of the brain. The aim of this proposal is to use an in vitro tissue culture system to determine whether endogenous oestrogens regulate the survival and outgrowth of gonadotropin releasing hormone (GnRH) and other hypothalamic neurons, and to investigate factors which regulate axon pathfinding during the initial development of GnRH neurons. This work is relevant to understanding the potentially adverse effects of exposure to environmental oestrogens during pregnancy on fertility in later life.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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