Award details

Isolation of novel complement inhibitors using baculovirus display technology

Reference	9810669
Principal Investigator / Supervisor	Professor Ian Jones
Co-Investigators / Co-Supervisors	Professor Patricia Nuttall
Institution	NERC Centre for Ecology and Hydrology
Department	Centre for Ecology and Hydrology (NERC)
Funding type	Research
Value (£)	77,552
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	01/01/2001
Duration	24 months

Abstract

The proposal seeks to isolate new inhibitors of the complement pathway. It makes use of the fact that baculoviruses are very sensitive to complement lysis and undergo a 4- or 5- log drop in titre when incubated with a complement active serum. Using our novel technology for the expression of foreign proteins on the surface of the baculovirus particle we propose the construction of baculovirus display libraries using cDNA from ticks known to encode complement inhibitor proteins. Expression of such proteins on the viral surface will allow the direct selection of viruses displaying complement inhibitor proteins when incubated with complement.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	ROPA 1998 (ROPA1998) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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