BBSRC Portfolio Analyser
Award details
How do proteins that enter mammalian cells via the endoplasmic reticulum avoid proteasomal degradation?
Reference
9810663
Principal Investigator / Supervisor
Professor Michael Lord
Co-Investigators /
Co-Supervisors
Professor Lynne Roberts
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
115,095
Status
Completed
Type
Research Grant
Start date
01/08/1999
End date
31/07/2002
Duration
35 months
Abstract
The quality control system of the endoplasmic reticulum (ER) is able to identify proteins that fail to fold or assemble correctly, targeting them for export to the cytosol to be degraded by the ubiquitin/proteasome system. Certain toxic proteins take advantage of the ER export machinery to reach the cytosol but must avoid subsequent degradation, and the proposed research aims to identify the strategies evolved to ensure that this is the case.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search