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RNA aptamers based on L-ribose as inhibitors of fibrillogenesis
Reference
9810660
Principal Investigator / Supervisor
Professor Peter Stockley
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
100,696
Status
Completed
Type
Research Grant
Start date
12/04/1999
End date
12/04/2001
Duration
24 months
Abstract
We propose to isolate RNA aptamers which inhibit aggregate formation of the beta- amyloid peptide (1-42). Such aptamers would have potential as lead compounds in treatment for Alzheimer's patients. However, whilst aptamers with high affinity for the target are extremely likely to be isolated, the instability of RNA molecules in biological media will prevent their effective clinical use. To overcome this problem we intend to take advantage of the natural chirality of biological macromolecules to isolate tight binding aptamers, based on the non-natural enantiomer, L-ribose, which will be stable in biological fluids. Further refinement of these molecules will then be possible using nucleotide functional group variants.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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