Award details

Development of tools to study mycotoxin production by Fusarium species

Reference	9810642
Principal Investigator / Supervisor	Professor Paul Nicholson
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	99,844
Status	Completed
Type	Research Grant
Start date	04/01/1999
End date	04/01/2001
Duration	24 months

Abstract

Fusarium ear blight (scab) of wheat is an economically important disease of cereals in the UK and many other parts of the world. As well as the loss of yield and quality, this disease is of particular concern because many of the Fusarium species which cause ear blight produce trichothecene mycotoxins which are harmful to human and animal health. This project aims to utilise recent advances in gene expression reporter systems to develop a series of transformants of F. culmorum and F. graminearum as tools to study the regulation of toxin production and inhibition of fungal growth. The transformants will be used to identify and characterise factors triggering/influencing mycotoxin production and/or inhibiting fungal growth. These tools will permit the development of rapid, sensitive, non-destructive, in vitro assays to identify compounds which prevent, or interfere with, mycotoxin synthesis and/or inhibit fungal growth.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	ROPA 1998 (ROPA1998) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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