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Circumventing sample processing and bio-interfacial problems of analytical biotechnology: sample-going sub-micron digital biosensors
Reference
9810636
Principal Investigator / Supervisor
Professor David Clarke
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Manchester Pharmacy School
Funding type
Research
Value (£)
87,899
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
01/04/2001
Duration
24 months
Abstract
The major problems of analytical biotechnology continue to be sample processing (reliably delivering trace analyte from complex samples in measurable form), the incompatibility problems of biorecognition with inorganic and polymer surfaces (non- specific background, sensitivity and reproducibility of biosensors and microwells) and the loss of spectroscopic information to the noise band. We have integrated molecular biosensing complexes into biocompatible and stable sub-micron assemblies producing amplified signal. The elimination of (in)organic interfaces, the deployment of these small, free biosensors into complex samples to find trace analyte, and the recovery of their digital signal presents a fundamentally new and untried approach to resolve these problems.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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