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Characterising and overcoming biological barriers to gene therapy
Reference
9810633
Principal Investigator / Supervisor
Professor Malcolm Rowland
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Manchester Pharmacy School
Funding type
Research
Value (£)
120,872
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
16/09/2001
Duration
29 months
Abstract
A major obstacle to successful therapy with biopharmaceuticals and genes is ineffective target tissue delivery, due to poor penetration. By developing novel quantitative microscopic techniques, Fluorescence Redistribution after Photo- bleaching and Fluorescence Correlation Spectroscopy, we will define and estimate the microscopic spatial distribution and associated diffusion coefficients in vivo of gene vectors (peptide, viral, liposome) in tumour, muscle, subcutaneous tissue, detect gene expression and investigate strategies for enhancing penetration of intestitial barriers, together crucial for realising the full benefits of gene and protein therapies.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1998 (ROPA1998) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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