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Award details
Development of a novel eukaryotic biosensor
Reference
9709012
Principal Investigator / Supervisor
Professor Lesley Glover
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
93,688
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/1999
Duration
24 months
Abstract
We will test the feasibility of genetically modifying the multicellular eukaryote Caenorhabditis elegans, as a biosenor for monitoring environmental and cellular toxicants. Gene fusions will be constructed with C. elegans promoters and a selection of reporter genes to prove the concept that a wide variety of bacterial and eukaryotic toxins in environmental samples can be sensed rapidly, sensitively and cheaply. The effectiveness of these novel biosensors will be compared to existing bacterial and unicellular eukaryote biosensors (developed in our laboratories) both for standard environmental toxins such as heavy metals and for eukaryote-specific compounds such as oestrogens.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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