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Use of AFM and CFM to determine biomolecular mechanisms controlling crystal growth in mammalian skeletal tissues
Reference
9709001
Principal Investigator / Supervisor
Professor Jennifer Kirkham
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Institute of Membrane & Systems Biology
Funding type
Research
Value (£)
88,095
Status
Completed
Type
Research Grant
Start date
08/06/1998
End date
08/06/2000
Duration
24 months
Abstract
Organic-inorganic interactions are fundamental to the modulation of hydroxyapatite crystal initiation, growth and resorption in skeletal tissues. While precise control mechanisms are unclear, specific crystal surface domains and stereochemical arrays on interacting proteins have been implicated. The proposed study will utilise the powerful new technologies of atomic and chemical force microscopy to determine the nature of the interactions involved and how control may be effected at the biomolecular level, using natural biological crystals and specific matrix proteins from skeletal tissues. This will provide unique information which will be pivotal to understanding tissue histogenesis, morphostasis and pathogenesis.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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