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Protein folding by motif recognition using threading
Reference
9708971
Principal Investigator / Supervisor
Professor Janet Thornton
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Structural Molecular Biology
Funding type
Research
Value (£)
95,506
Status
Completed
Type
Research Grant
Start date
01/11/1997
End date
01/11/1999
Duration
24 months
Abstract
This project will attempt protein folding from sequence, by motif recognition using threading. The project will use a library of supersecondary motifs (e.g. beta hairpins, beta alpha beta units) and develop software to thread a new sequence (or multiple sequence alignment) against the library of motifs. Each hit will be scored and the fold then constructed by combining the motifs into tertiary folds, using heuristic rules derived from known structures.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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