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Structure of human phosphatidylethanolamine- binding protein - a new family of proteins associated with bilipid membranes
Reference
9708944
Principal Investigator / Supervisor
Professor R Brady
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
72,836
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/1999
Duration
24 months
Abstract
Phosphatidylethanolamine-binding proteins (PBP's) are a recently discovered family of proteins believed to be involved in the biogenesis and maintenance of specialised bilipid membranes such as those found in myelin sheath and spermatozoa. Although extremely well conserved between species, these proteins have no significant recognisable homology to other proteins. We have crystals of human PBP that diffract to beyond 2 A, and in this project plan to determine the structure of human PBP using MIR and MAD phasing. We hope these studies will help delineate the precise role of PBP, and stimulate interest in the novel field of membrane biogenesis.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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