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Allosteric modulation of biogenic amine G-protein coupled receptors by endogenously released neuropeptides
Reference
9708942
Principal Investigator / Supervisor
Dr Peter Evans
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
80,268
Status
Completed
Type
Research Grant
Start date
01/12/1997
End date
01/12/1999
Duration
24 months
Abstract
A combination of molecular biological and physiological approaches will be used to identify neuropeptides capable of allosterically modulating G-protein coupled receptors for the biogenic amine, octopamine. Putative neuropeptides from this class will be identified as cDNAs selectively expressed by insect octopaminergic neurones using PCR-select cDNA subtraction. These neuropeptides will be synthesised and screened for their ability to modulate octopamine receptors, both in intact preparations and also in clonal cell lines heterologously expressing cloned octopamine receptors.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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