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Award details
A novel procedure to generate selenium-derivatised proteins for structural analysis
Reference
9708929
Principal Investigator / Supervisor
Professor John McCarthy
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
87,067
Status
Completed
Type
Research Grant
Start date
15/01/1998
End date
15/01/2000
Duration
24 months
Abstract
This project will develop a novel approach to solving the phase problem of X-ray crystallography. Leaning on our experience in studies of selenoprotein biosynthesis, we will construct and optimise novel systems that direct selenocysteine incorporation into proteins encoded by genes cloned into a new type of vector construction. Incorporation systems for animal and insect cell lines, and for yeast, will be established and optimised. Via collaborative work we will perform proof of concept studies on two test proteins that will be subjected to crystallisation trials and X-ray analysis.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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