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Real-time observation of the interaction between hydrolytic enzymes and single molecules of polysaccharides
Reference
9708918
Principal Investigator / Supervisor
Professor Gary Williamson
Co-Investigators /
Co-Supervisors
Institution
Quadram Institute Bioscience
Department
Quadram Institute Bioscience Department
Funding type
Research
Value (£)
47,021
Status
Completed
Type
Research Grant
Start date
01/04/1998
End date
01/04/1999
Duration
12 months
Abstract
Current knowledge on the complex branched and substituted structure of polysaccharides has been obtained by techniques such as chemical and enzymic hydrolysis, light scattering and chromatography. These techniques give an average value, which does not reflect the true heterogeneous nature of plant cell wall polysaccharides. The real distribution of substitutions on a pectin molecule, how arabinoxylans are linked together and the distribution of cross- links between molecules is unknown. We aim to develop new atomic probe methodologies to observe individual molecules of polysaccharides, and observe real-time changes in these molecules after hydrolysis or binding by specific proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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