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Conformations and folding of proteins in vacuo
Reference
9708907
Principal Investigator / Supervisor
Professor Peter Derrick
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
University of Warwick Department
Funding type
Research
Value (£)
94,083
Status
Completed
Type
Research Grant
Start date
06/01/1998
End date
31/03/2000
Duration
27 months
Abstract
Conformations of calcium-binding and other protein ions in vacuo will be studied by electrospray ionisation coupled with Fourier transform ion cyclotron resonance. Gradual unfolding of gaseous protein ions will be induced by controlled pulsed-laser irradiation at selected infra-red wavelengths. The progress of unfolding will be monitored through hydrogen/deuterium exchange and proton transfer reactions. An objective will be to elucidate the relationships between gas-phase conformations and those in solution.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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