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The ADAM disintegrin module - an optimised cell surface targeting system?
Reference
9708897
Principal Investigator / Supervisor
Professor Martin Humphries
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
82,982
Status
Completed
Type
Research Grant
Start date
19/01/1998
End date
19/01/2000
Duration
24 months
Abstract
This proposal will test the hypothesis that a small disintegrin module found in the newly discovered ADAM family of cell surface metalloproteinases is able to bind adhesion receptors and thereby target proteolytic activity to regions of cell-extracellular matrix contact. If proven, the importance of this hypothesis centres on the potential exploitation of the disintegrin module as a cellular targetting vehicle for pseudo-physiological delivery of therapeutic agents. This is uncharted territory in the adhesion field, but has enormous promise. A direct strategy is outlined to test disintegrin-adhesion receptor binding, cellular targeting, and characterisation of the key molecular properties of the disintegrin that determine targeting activity.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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