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Predicting metabolic potential in streptomycetes from genotypic and phenotypic data
Reference
9708894
Principal Investigator / Supervisor
Professor Michael Goodfellow
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
Sch of Biology
Funding type
Research
Value (£)
88,787
Status
Completed
Type
Research Grant
Start date
04/05/1998
End date
04/05/2000
Duration
24 months
Abstract
Rapid genotypic and phenotypic characterisation of Streptomyces cyaneus and related organisms will be performed using 16S rDNA, 16S - 23S spacer DNA sequencing and pyrolysis mass spectrometry. The sequence data will be used to establish a fine structure taxonomy of this cluster of anthracycline producing strains. The phenotypic structure, determined using pyrolysis mass spectrometry over a range of growth conditions, will be mapped onto the sequence data. The pattern of production of poly-ketide anthracyclines will be determined by this layer chromatography. The complete data set will be used to evaluate the ability to map natural products to the phylogenetic tree.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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