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Contraceptive/immunosuppressive carbohydrates?
Reference
9708874
Principal Investigator / Supervisor
Professor Steven Ley
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
85,847
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/1999
Duration
24 months
Abstract
Glycodelin-A (GdA, also known as placental protein 14 or progesterone-associated endometrial protein) isolated from amniotic fluid, suppresses responses by a variety of different immune effector cell types and also inhibits human sperm-zona pelucida binding under hemizona assay conditions. Glycodelin-S (GdS), found in human seminal plasma, is immunologically indistinguishable from GdA but does not display contraceptive properties. It has been suggested that the origin of their different properties is due to the differences in their glycans. The specificity of the activity may be dependent on non-covalent interactions between the epitopes and one or more receptors, it is the nature of this interaction that we wish to investigate and exploit.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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