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The control of heparanase expression in blood leucocytes: implications for function of the vascular capillary wall
Reference
9708860
Principal Investigator / Supervisor
Professor Paul Brenchley
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Medical and Human Sciences
Funding type
Research
Value (£)
46,305
Status
Completed
Type
Research Grant
Start date
09/03/1998
End date
09/03/1999
Duration
12 months
Abstract
The role of heparan sulphate glucosaminoglycan in controlling the communication between cells and extracellular matrix has been identified using exogenous bacterial heparanases. There is firm evidence that most classes of leucocyte can express heparanase activity but the identity and control of heparanase genes in these cells is poorly defined. This project seeks to confirm NAP-2 derivatives as heparanases, not only in platelets but in blood leucocytes in general. The control of heparanase gene expression will be studied using promoter constructs in reporter gene assays and specific control of mRNA will be sought using both physiological and inflammatory stimuli.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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