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Aptamers against glycosaminoglycans
Reference
9708851
Principal Investigator / Supervisor
Professor William James
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Sir William Dunn Sch of Pathology
Funding type
Research
Value (£)
51,221
Status
Completed
Type
Research Grant
Start date
01/08/1997
End date
01/08/1998
Duration
12 months
Abstract
Because of the potentially great importance of glycosaminoglycans (GAGs) in biological systems and because of the dearth of high-specificity reagents for studying them at the cellular level, we propose to isolate and characterise GAG-binding RNA aptamers. Aptamers are nucleic acids that are isolated from large libraries containing random sequence elements by successive rounds of in vitro selection and reamplification. The challenge here is to overcome the natural repulsion between GAGs and RNA in order to isolate aptamers that have sufficient affinity and specificity to enable them to be used to identify, block or modify specific sequences of sulphated aminosugars.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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