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Award details
Solid phase dendrimer synthesis and the generation of super high loading resin beads for combinatorial chemistry
Reference
9708849
Principal Investigator / Supervisor
Professor Mark Bradley
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Sch of Chemistry
Funding type
Research
Value (£)
96,741
Status
Completed
Type
Research Grant
Start date
12/01/1998
End date
12/01/2000
Duration
24 months
Abstract
The ability to enhance resin loading by an order of magnitude would have major practical application in single bead screening in combinatorial chemistry. In this proposal we aim to enhance resin loading by the solid phase synthesis of dendrimers. Initial work will be focused on PAMAM type dendrimers on 250 micrometre polystyrene beads with the aim of producing beads with a loading of 1 micro mol. This would be expanded to polyether type dendrimers to enhance chemical utility through increased chemical resistance and to the dendrimerisation of the Chiron Pin/Crowns thus increasing the loading of the smallest crown to a useful 16 micro moles.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 1997 (ROPA1997) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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