BBSRC Portfolio Analyser
Award details
Characterisation of molecules expressed specifically on subsets of follicular dendritic cells
Reference
0014938
Principal Investigator / Supervisor
Professor Bryan Charleston
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
90,136
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2003
Duration
24 months
Abstract
Follicular dendritic cells (FDCs) in the germinal centres of secondary lymphoid tissue are pivotal for the affinity maturation of antibody responses and maintenance of immunological memory. Monoclonal antibodies that delineate FDCs in the dark zone, basal light zone or throughout the germinal centres in ruminants have been identified. Some of the patterns of FDC staining have not been described previously in any species. The project aims to clone cDNAs encoding these molecules in ruminants and mice to determine their role in regulating B cell activation and differentiation. Murine cDNAs will facilitate the longer-term aim of investigating the in vivo functions of these molecules.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search