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Gal transferase induced ablation of undifferentiated human ES cells
Reference
0014935
Principal Investigator / Supervisor
Dr James McWhir
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
Gene Expression and Development
Funding type
Research
Value (£)
119,712
Status
Completed
Type
Research Grant
Start date
02/07/2001
End date
03/10/2003
Duration
27 months
Abstract
Transplantation therapy using ES-derived cell types following in vitro differentiation is accompanied by a risk of contamination with undifferentiated and potentially tumorigenic ES cells. The objective of this project is to modify human ES cells such that undifferentiated cells express a xenotransplantation epitope (1,3 gal) which renders them sensitive to complement mediated lysis in vivo. We will also investigate the feasibility of rendering the expression of the catalytic subunit of the telomerase enzyme (hTERT) inducible in culture as a means of prolonging the proliferative life span of differentiated cells.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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