BBSRC Portfolio Analyser
Award details
Design synthesis and evaluation of a synthetic NCS surrogate
Reference
0014877
Principal Investigator / Supervisor
Professor Stephen Caddick
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Chemistry
Funding type
Research
Value (£)
126,824
Status
Completed
Type
Research Grant
Start date
21/09/2001
End date
21/09/2003
Duration
24 months
Abstract
NCS chrom is a highly reactive species which binds to proteins and nucleic acids and has many potential exciting applications. However its instability is a serious barrier to further development work. We propose to prepare a surrogate for NCS chrom in which we replace the strained dienediyne ring with an alternative biradical precursor. This surrogate should be more stable than NCS chrom but retain the ability to bind to NCS apoprotein and nucleic acids; these properties will be evaluated.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search