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Effects of extracellular matrix proteins on calcium mobilisation in hypertrophied right ventricular myocytes
Reference
0014871
Principal Investigator / Supervisor
Professor Christopher Garland
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Pharmacy and Pharmacology
Funding type
Research
Value (£)
92,256
Status
Completed
Type
Research Grant
Start date
23/04/2001
End date
22/02/2004
Duration
34 months
Abstract
It is proposed to see if changes in extracellular matrix proteins impair cardiac function by interfering with signalling mechanisms that regulate calcium and contractility. The effects of matrix proteins secreted by fibroblasts from normal and hypertrophied hearts, on calcium transients and cell shortening changes induced by receptor and non-receptor-mediated events, will be examined in myocytes from control and hypertrophied hearts. Despite regional differences in the expression of receptors and ion channels the right ventricle is rarely studied. Consequently this study will compare right and left ventricular myocytes from hearts with right ventricular hypertrophy induced by chronic hypoxia.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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