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Fungal hypha orientation responses; role in pathogenesis
Reference
0014870
Principal Investigator / Supervisor
Professor Neil Andrew Robert Gow
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
81,019
Status
Completed
Type
Research Grant
Start date
04/07/2001
End date
04/04/2003
Duration
21 months
Abstract
To investigate the mechanism and significance of hyphal orientation of hyphae of the human pathogenic fungus Candida albicans in relation to thigmotrophic and galvanotropic hyphal orientation responses and tissue invasion. Specifically, we will test the hypothesis that stretch-activated and voltage-gated calcium channels act as transducers for thigmotrophic orientation and regulators of hyphal growth by: (a) analysing the behaviour of null mutants in C. albicans CCH1 and MID1 Ca2+ channel genes; (b) examining the response of mutants in other relevant signalling and transcription factor genes and (c) assessing the virulence of these mutants in a range of assays of pathogenicity.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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