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Involvement of proteinase activated receptors in neuro-immune signalling and inflammation in the gastrointestinal tract
Reference
0014848
Principal Investigator / Supervisor
Professor David Grundy
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Biomedical Science
Funding type
Research
Value (£)
116,952
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
01/08/2003
Duration
24 months
Abstract
The recent discovery that sensory neurones express cell surface proteinase-activated receptors (PARs) has major implications for our understanding of inflammation. PARs depend on proteolytic activity of trypsin, thrombin and mast cell protease to initiate G-protein coupled cell signalling. The arrangement of sensory neurones in the gastrointestinal mucosa and their potential exposure to proteases from different sources is the basis of the current hypothesis that these sensory nerve endings are directly stimulated by different PARs. This hypothesis will be tested using confocal microscopy and electrophysiological recording techniques to determine the morphological and functional basis of this novel aspect of neuroimmune signalling.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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