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Characterising enzymes involved in phase IV pesticide metabolism in Arabidopsis mutants
Reference
0014839
Principal Investigator / Supervisor
Professor Robert Edwards
Co-Investigators /
Co-Supervisors
Institution
Durham University
Department
Biological and Biomedical Sciences
Funding type
Research
Value (£)
36,243
Status
Completed
Type
Research Grant
Start date
09/07/2001
End date
09/07/2002
Duration
12 months
Abstract
In the course of their metabolism in plants, many pollutants and pesticides (xenobiotics) become covalently incorporated into natural biopolymers. Although these 'bound' residues are of toxicological concern, the routes of phase IV metabolism leading to their formation are unknown. In order to dissect phase IV metabolism, in a one year pump-priming programme it is proposed to screen EMS-mutagenised Arabidopsis plants for individuals which have altered capacities to incorporate radiolabelled xenobiotics into bound residues. These mutants will then be biochemically characterised to identify how the metabolism and distribution of thexenobiotics has been affected.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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