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Anti-CD40 antigen conjugates and CTL responses
Reference
0014837
Principal Investigator / Supervisor
Dr A Heath
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Genomic Medicine
Funding type
Research
Value (£)
104,716
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2003
Duration
24 months
Abstract
We have shown that antibody against CD40 has a very potent adjuvant effect for antibody and type 1 helper responses when physically attached to antigen. Other groups have shown that cytolytic T lymphocyte (CTL) responses can be enhanced by very large doses of CD40 antibodies, which would be unacceptable for prophylactic immunisation. This proposal is designed to assess the potential for low doses of anti-CD40 antibody-antigen conjugates to enhance CTL responses against a known CTL epitope of ovalbumin, as well as CTL peptides derived from Bovine Leukaemia virus and Bovine herpes virus.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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