BBSRC Portfolio Analyser
Award details
Delivery of artificial chromosomes in vivo via a virus vector system
Reference
0014798
Principal Investigator / Supervisor
Professor John Quinn
Co-Investigators /
Co-Supervisors
Institution
University of Liverpool
Department
Human Anatomy and Cell Biology
Funding type
Research
Value (£)
126,928
Status
Completed
Type
Research Grant
Start date
22/11/2001
End date
22/11/2003
Duration
24 months
Abstract
We will explore the viability of a virus vector model to complement or replace transgenic experiments to determine transcriptional regulators of gene expression and gene function in vivo. This is a procedure that would significantly reduce the number of animals used in such research and increase the throughput to look at effect of mutation on function. Further it would be an advance in the generation of vectors for gene therapy, which exhibit appropriate gene expression of the transgene. We propose to use a herpesvirus packaging system to allow chromosomal fragments up to 150Kb plus to be packaged within an HSV-1 virion.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
ROPA 2000 (ROPA2000) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search